Degenerative Joint Disease Low back ache and osteoarthritis of the knee are both extra common in overweight men and women. Obese women are 4 times more likely and overweight men five times more likely to broaden osteoarthritis of the knees. Fortunately, the associated knee pain and disability enhance or solve with weight loss. According to the Framingham Study, an eleven pound weight loss in women decreased their chance for knee osteoarthritis via 50%. The degree of development varies with the amount of structural damage but remedy can commonly be complete with slight weight loss.